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I don’t know about the AP exam. #gmail. Submitted By: Guest. on 12 November 2012. Downloaded: 3321 times. File size: 69 KB. Rating:.Overweight and the timing of menarche. Overweight is an established risk factor for early menarche. This study examines the association between overweight and earlier age at menarche in a large cohort of adolescent schoolgirls. The study consists of 74,231 girl-years of follow-up of participants from birth to age 15 years from the Longitudinal Study of Australian Children. Girls were originally recruited from the community and followed to age 15 years. The cohort was divided into those who had never been overweight and those who were overweight at one or more clinic visits. Cox regression was used to examine the association between overweight and age at menarche. The mean age at menarche was 12.9 years for girls who were never overweight and 12.4 years for girls who were overweight at one or more clinic visits. Compared to girls who were never overweight, the adjusted hazard ratio for menarche at age 13.5 years was 0.93 (95% confidence interval: 0.91 to 0.96) for girls who were overweight at one or more clinic visits. In this large cohort, overweight was not associated with earlier age at menarche.Topical AZD2171 in a clinical phase I study: an integrated biopharmaceutical and bioengineering strategy. Topical AZD2171, a water soluble derivative of AZD2171, is a non-steroidal, orally active GRPR antagonist with demonstrated efficacy in inhibiting human tumour growth in both preclinical xenograft and murine models. It also possesses low toxicity and in particular has high plasma exposure. Topical delivery of AZD2171 therefore enables a potential first-line treatment option for breast cancer patients that already have metastatic disease. This clinical study evaluated the tolerability and maximum tolerated dose of AZD2171 (5%, 10% or 30% w/w) as an aqueous formulation (Ettunate, Eucap Pharmaceuticals Pty Ltd.) in healthy volunteers. The pharmacokinetics and bioavailability of AZD2171 following topical application of 5% or 10% w/w were also studied. AZD2171 was found to be well tolerated at doses up to 30% w/w, with local skin reactions being the most frequently observed adverse event. Systemic absorption was negligible